The key here is that it doesn't matter what the characters are searching for, as long as they are searching for something, and it doesn't matter where they go. Vital components include the hero (or heroine); a 'call to adventure', some companions who help and support the hero, but with whom their will be conflict and a perilous journey. On arrival, or near arrival, the hero/heroine will meet some final frustration or impediment. There will be a last test, or tests, and then the final goal will be achieved.
And you can go towards the light and frothy - as in Around the World in 80 days - or dark. As in Conrad's Heart of Darkness or its cinematic alter ego Apocalypse Now.
Sounds so incredibly easy I think I will start penning my Quest novel right now.